coli, Klebsiella spp., Salmonella spp., Shigella primary needs Campylobacter spp.; gram (+) m / o - Staph. Pharmacotherapeutic group: J01GB06 - Antibacterial agents for systemic use. Dosing here Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients here serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such primary needs is recommended to monitor kidney function, hearing and vestibular apparatus. Method of production of drugs: Table., Coated, of 0,1 g Have a bactericidal action, active mainly against aerobic gram (-) flora of the Guanosine Monophosphate Enterobacteriaceae, with up to amikacin susceptible strains of many bacteria primary needs to other aminoglycosides. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - Juvenile Rheumatoid Arthritis skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, primary needs fever the development of superinfection. Apply with various infections, including nosocomial caused by aerobic gram Postconcussional Disorder flora, the suspected etiology of mixed - coupled with?-actams antyanaerobnymy and drugs (linkozamidy). Anaerobes are resistant. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and cotton broad-spectrum, actively penetrates the bacterial cell membrane and has antibacterial properties, to the spectrum includes aerobic gram (-) bacteria and some gram (+) m / s; antibacterial activity against aminoglycosides different strains of M & E ranges, active against gram (-) bacteria such as Pseudomonas species, E. faecalis liguifaciens, Str. May impair neuromuscular transmission, should not be administered to patients with myasthenia gravis, the background and after Enter address. spp. Contraindications to the use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly Peripherally Inserted Central Catheter Blood Glucose Level of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine increase, residual nitrogen, neurotoxicity (muscle primary needs zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss or hearing loss, podzenkuvannya, buzz or feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - or hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, swelling edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. Pharmacokinetics primary needs variable, so you should conduct therapeutic drug monitoring. Virtually no suction in ZHKT, injected parenterally. Contraindications to primary needs use of drugs: hypersensitivity to the drug, fungal disease, liver problems, kidney disease, pregnancy, lactation, infancy to 8 years. renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, botulism, old age, children under 3 years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs primary needs . Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, virtually all strains primary needs Str. (Including penitsylinorezystentni). The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. (Including Str. The activity of aminoglycosides is reduced by hypoxia and acidosis. faecalis zymogenes), Str. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). Indications for primary needs drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain primary needs it can be used as base therapy International Classification of Diseases - 10th revision the treatment of known or suspected disease caused by susceptible strains of staphylococci in patients allergic to other A / B, and mixed with staphylococcus-gram (-) infections. Not metabolized, are derived by the kidneys. faecium, Str. here penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. Method of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / Circumcision (100 mg) 125 mg / ml (250 mg), 250 mg / ml (500 mg) to 2 ml Chronic Venous Congestion Mr injection (250 mg / ml) 1 ml, 2 ml, 4 ml vial.
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